EXPERIMENTAL-STUDY ON CLEFT-LIP AND OR PALATE - FETUSES OF A/J MICE IN UTERI OF F1-HYBRID MOTHERS USING OVARIAN TRANSPLANTATION/

The A/J inbred strain of mice spontaneously develops cleft lip and/or palate (CL/P), Ovarian transplantation and several test-matings with C 57BL/6 strain mice (0% CL/P) were performed to investigate a relations hip between mother and fetus in regard to this order. The fetuses obta ined showed that regardless of whether the genetic background of the m other was A/J or F1, CL/P was produced only in cases where the fetuses were genetically pure A/J, CL/P frequency was 7.46% in A/J fetuses de veloped in A/J mothers; it was 5.88% in F1 mothers with transplanted A /J ovaries, Isolated cleft palate (CP) and cleft lip with cleft palate (CLP) were found in A/J mothers, However, the frequency of CP was low er in F1 mothers than in A/J mothers, These results suggest that the o ccurrence of CLP depends more on the genetic constitution of the fetus than on maternal environmental factors, and the occurrence of CP was influenced by the mother's condition.