Jt. Cody, ENANTIOMERIC COMPOSITION OF AMPHETAMINE AND METHAMPHETAMINE DERIVED FROM THE PRECURSOR COMPOUND FAMPROFAZONE, Forensic science international, 80(3), 1996, pp. 189-199
Fourteen different metabolic precursors of amphetamine or methamphetam
ine have previously been identified. Many of these drugs are available
only by prescription and several are only available in some parts, of
the world and not in others. One of these drugs, famprofazone, is ava
ilable over-the-counter which complicates the interpretation of metham
phetamine urine drug testing results. To assist in the interpretation
of typical laboratory results, a study was conducted to determine the
enantiomeric composition of the methamphetamine and amphetamine produc
ed from the metabolism of famprofazone. Fifty mg of famprofazone was a
dministered to a volunteer followed by collection of urine for the nex
t 6 days. The resulting quantity, enantiomeric composition and percent
conversion from famprofazone to the product amphetamine and methamphe
tamine was determined. The results showed the amphetamine and methamph
etamine to include both the d- and l-enantiomers. Percent conversion a
nd peak concentrations were similar to those reported in previous stud
ies.