ENANTIOMERIC COMPOSITION OF AMPHETAMINE AND METHAMPHETAMINE DERIVED FROM THE PRECURSOR COMPOUND FAMPROFAZONE

Fourteen different metabolic precursors of amphetamine or methamphetam ine have previously been identified. Many of these drugs are available only by prescription and several are only available in some parts, of the world and not in others. One of these drugs, famprofazone, is ava ilable over-the-counter which complicates the interpretation of metham phetamine urine drug testing results. To assist in the interpretation of typical laboratory results, a study was conducted to determine the enantiomeric composition of the methamphetamine and amphetamine produc ed from the metabolism of famprofazone. Fifty mg of famprofazone was a dministered to a volunteer followed by collection of urine for the nex t 6 days. The resulting quantity, enantiomeric composition and percent conversion from famprofazone to the product amphetamine and methamphe tamine was determined. The results showed the amphetamine and methamph etamine to include both the d- and l-enantiomers. Percent conversion a nd peak concentrations were similar to those reported in previous stud ies.