COMPARISON OF GERMAN POPULATION-DATA ON THE APO-B-HVR LOCUS WITH OTHER CAUCASIAN, ASIAN AND BLACK POPULATIONS

A population study of 505 unrelated individuals from Southwestern Germ any was carried out on the 3'-apoB hypervariable region (HVR). After a mplification via polymerase chain reaction (PCR) and agarose gel elect rophoresis, 15 different alleles and 47 genotypes were observed. The m ost common alleles were hypervariable elements (HVE) 37 and 35 with an allele frequency of 0.374 and 0.244, respectively. The heterozygosity index was calculated to be 78.4%. Allele frequencies of this study ar e compared with results from other databases obtained from a French, a Spanish, an Asian and an American (Black) population.