PARTITION OF POLY(OXYETHYLENE)S WITH 5-CHLORO-8-QUINOLINOXYL END-GROUPS BETWEEN 1-OCTANOL AND WATER

Apparent partition coefficients for a series of poly(oxyethylene)s wit h 5-chloro-8-quinolinoxyl end-groups and different polyether chain len gths; POE(400), POE(1000)*, POE(2000)*, and POE(3000)* (the subscript s show the molecular weight of the polyether chain) were determined fo r the system 1-octanol/water at different pHs at 37 degrees. The parti tion coefficient was found to decrease with increasing polyether chain length. The substituent constants were calculated and the effect of t he substituents on the partition behavior of the compounds was estimat ed. The antibacterial effect of POE on gram-positive and gram-negativ e bacteria was found to be lower than that of CHQ. The activity of POE slightly increased in the presence of Fe3+ ions.