Thirty-eight subjects identified in a large community survey were foun
d to attribute their fatigue to 'myalgic encephalomyelitis' (ME). They
were matched randomly to two other groups of subjects who attributed
their fatigue to either psychological or social factors. All three gro
ups were followed up 18 months later and were asked to complete a seri
es of questionnaires that examined fatigue, psychological distress, nu
mber of symptoms, attributional style and levels of disability. At ons
et the 'ME' group were found to be more fatigued, had been tired for l
onger but were less psychologically distressed than the other two grou
ps. At follow-up the 'ME' group were more handicapped in relation to h
ome, work, social and private leisure activities, even when controllin
g for both duration of fatigue and fatigue at time 1, but were less ps
ychologically distressed. The relationships between psychological dist
ress, specific illness attributions, attributional style and their eff
ect on the experience of illness and its prognosis are discussed. Attr
ibuting fatigue to social reasons appears to be most protective.