URINARY ALUMINUM EXCRETION IN PATIENTS WITH CHRONIC-RENAL-FAILURE IN TREATMENT WITH CONVENTIONAL LOW-PROTEIN DIET AND KETOANALOGS SUPPLEMENTATION - HORMONAL CHANGES

Recently, many clinic observations and experimental studies have agree d to resolve the problem of the aluminum (Al) intoxication in uremic p atients, supplying all the elements indispensable to Al settlement as an important uremic toxin, cause of remarkable morbidity and mortality . The evaluation of Al chronic accumulation in uremic patients is a co ntroversial question, especially in patients with initial renal insuff iciency and not yet on dialysis. We have already demonstrated that ini tial chronic renal failure (CRF) causes an increased urinary excretion of Al, even after interruption of Al pharmacological intake for month s. This work aims to evaluate urinary excretion capacity of Al on vari ous levels of renal function in relation to hormonal alterations induc ed by CRF. The data of PTH in the studied groups do not support its ro le in Al absorption in CRF patients. So, it seems that prolactin is no t responsible for increased urine excretion of Al in various groups.