SERUM COPPER LEVELS AND LIPID PROFILE OF ISCHEMIC-HEART-DISEASE PATIENTS AND HYPERTENSIVES

We studied 210 ischemic heart disease patients [stable angina, n = 70; unstable angina, n = 70; and MI, n = 70 (post infarction)], hypertens ives, n = 70 and normals, n = 70 of 40-60 years age group of males. Se rum copper and lipid profile was estimated in all the subjects. Blood pressure was recorded using spygmomanometer. Diet and other risk facto rs were also recorded. High serum copper levels were observed in major ity cases of IHD and hypertensives. Serum Total-C and LDL-C were high in unstable angina cases. HDL-C was low in myocardial infarction cases . A highly significant difference of serum lipids, copper, blood press ure and BMI was observed between the groups. Grade I obesity was obser ved in unstable angina. A highly significant difference of nutrient in takes was observed between the groups. A significant relationship of s erum copper with Total-C and triglycerides was observed in stable angi na. An inverse relationship of HDL-C and serum copper, HDL-C/Total-C a nd Cu was observed in unstable angina. A significant relationship of s erum Cu and LDL-C/HDL-C was observed in unstable angina. An inverse re lationship of serum HDL-C with Cu was observed in MI cases. A highly s ignificant relationship of serum Cu and PUFA, fiber and significant re lationship with P/S ratio was observed in patients. This study confirm s the hyperlipidemic effect of copper in cardiovascular diseases.