TUMOR-NECROSIS-FACTOR PRIMES NEUTROPHILS TO KILL STAPHYLOCOCCUS-AUREUS BY AN OXYGEN-DEPENDENT MECHANISM AND PLASMODIUM-FALCIPARUM BY AN OXYGEN-INDEPENDENT MECHANISM

Citation
Ic. Kowanko et al., TUMOR-NECROSIS-FACTOR PRIMES NEUTROPHILS TO KILL STAPHYLOCOCCUS-AUREUS BY AN OXYGEN-DEPENDENT MECHANISM AND PLASMODIUM-FALCIPARUM BY AN OXYGEN-INDEPENDENT MECHANISM, Infection and immunity, 64(8), 1996, pp. 3435-3437
Citations number
18
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
ISSN journal
00199567
Volume
64
Issue
8
Year of publication
1996
Pages
3435 - 3437
Database
ISI
SICI code
0019-9567(1996)64:8<3435:TPNTKS>2.0.ZU;2-C
Abstract
The cytokine tumor necrosis factor (TNF) plays the important role of p riming neutrophils for increased antimicrobial activity. We now demons trate that human neutrophils which lack the ability to generate oxygen radicals, from patients with chronic granulomatous disease, show TNF- induced enhancement of killing of intraerythrocytic stages of Plasmodi um falciparum but not of Staphylococcus aureus.