TUMOR-NECROSIS-FACTOR PRIMES NEUTROPHILS TO KILL STAPHYLOCOCCUS-AUREUS BY AN OXYGEN-DEPENDENT MECHANISM AND PLASMODIUM-FALCIPARUM BY AN OXYGEN-INDEPENDENT MECHANISM
Ic. Kowanko et al., TUMOR-NECROSIS-FACTOR PRIMES NEUTROPHILS TO KILL STAPHYLOCOCCUS-AUREUS BY AN OXYGEN-DEPENDENT MECHANISM AND PLASMODIUM-FALCIPARUM BY AN OXYGEN-INDEPENDENT MECHANISM, Infection and immunity, 64(8), 1996, pp. 3435-3437
The cytokine tumor necrosis factor (TNF) plays the important role of p
riming neutrophils for increased antimicrobial activity. We now demons
trate that human neutrophils which lack the ability to generate oxygen
radicals, from patients with chronic granulomatous disease, show TNF-
induced enhancement of killing of intraerythrocytic stages of Plasmodi
um falciparum but not of Staphylococcus aureus.