HUMAN METABOTROPIC GLUTAMATE-RECEPTOR TYPE-7 - MOLECULAR-CLONING AND MESSENGER-RNA DISTRIBUTION IN THE CNS

Authors
MAKOFF A PILLING C HARRINGTON K EMSON P
Citation
A. Makoff et al., HUMAN METABOTROPIC GLUTAMATE-RECEPTOR TYPE-7 - MOLECULAR-CLONING AND MESSENGER-RNA DISTRIBUTION IN THE CNS, Molecular brain research, 40(1), 1996, pp. 165-170
Citations number
26
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
40
Issue
1
Year of publication
1996
Pages
165 - 170
Database
ISI
SICI code
0169-328X(1996)40:1<165:HMGT-M>2.0.ZU;2-P
Abstract
Human metabotropic glutamate receptor type 7 (mGluR7) cDNA clones were isolated from a medulla cDNA library. The sequence, which includes a polymorphism, has 92% DNA sequence identity with rat mGluR7 and the pr edicted protein sequence has 99% identity. In-situ hybridization studi es on human brain sections showed that mGluR7 mRNA has a widespread di stribution with highest levels in the hippocampal formation, cerebral cortex and cerebellum.