NO EVIDENCE FOR ASSOCIATION OF DOPAMINE D2 RECEPTOR VARIANT (SER311 CYS311) WITH MAJOR PSYCHOSIS/

We investigated a variant of the dopamine D2 receptor gene (Ser311/Cys 311 substitution) in Caucasian patients with schizophrenia (n = 273), delusional disorder (n 62), bipolar I affective disorder (n = 63), and controls (n = 255), No evidence for association between the receptor variant and any of the diseases was found, even when patients with you nger age-of-onset (<25 years) were compared with controls, Furthermore , in a subgroup of schizophrenia patients whom we assessed for negativ e symptoms, those with the Cys allele did not differ from the remainde r of the group, Also, the bipolar affective disorder patients with psy chotic features did not show evidence for association with the recepto r variant, Thus, our results do not provide evidence for an associatio n between this D2 receptor variant and schizophrenia, or delusional di sorder, or bipolar affective disorder. (C) 1996 Wiley-Liss, Inc.