APPLICATION OF TERTIARY-AMINES FOR ARSENIC AND SELENIUM SIGNAL ENHANCEMENT AND POLYATOMIC INTERFERENCE REDUCTION IN ICP-MS ANALYSIS OF BIOLOGICAL SAMPLES

Water soluble tertiary amines enhance signals and decrease polyatomic chloride interferences in the direct inductively coupled plasma - mass spectrometric (ICP-TUIS) determination of As and Se in biological sam ples. Preliminary experiments with amine concentrations and nebulizer flow rates produced element and interference signal intensity changes. Arsenic and Se ICP-MS determination parameters have been optimized by a simplex procedure with amines in an argon plasma or without amines but with addition of N-2, to the Ar. Variables include RF (radio frequ ency) power, nebulizer gas flow rate, intermediate gas flow rate, and amine concentration or nitrogen gas flow rate. Detection limit, minimi zation of polyatomic ion intensities, and reproducibility have been ev aluated as reponse factors. The signal enhancement and element-to-mole cular interference ratios differ to some extent with analyte intensity optimum operating conditions. The detection limits with addition of n itrogen (16 pg mL(-1) for As and 180 pg mL(-1) for Se) or of amines (8 pg mL(-1) for As and 120 pg mL(-1) for Se) and the extent of chloride interference minimization were compared. Amines addition was more ben eficial. Biological standard reference materials and food and fecal sa mples were analyzed following different sample dissolution procedures.