SELECTIVITY IN THE BINDING AND DETECTION OF CHARGE DIFFUSE IONS

The selective binding of charge diffuse alkyl and arylammonium ions re lies upon multiple weak interactions with a complementary synthetic re ceptor. Using appropriately sized lipophilic cyclodextrin derivatives, the chemoselective binding of alkylammonium ions such as dopamine, ac etyl choline, guanidine, and long chain cationic surfactants may be ac hieved allowing their selective detection by either potentiometric or amperometric methods of analysis. Enantioselectivity in the binding of chiral beta-hydroxyarlammonium ions, such as propranolol, allows chir al sensors to be developed. The selective detection of various clinica lly important analytes, such as imipramine, lignocaine and creatinine has also been studied.