Periradicular curettage is a part of the treatment procedure of perira
dicular surgery, Its main purpose is to remove pathological periradicu
lar tissues for visibility and accessibility to facilitate the treatme
nt of the apical root canal system, or sometimes for the removal of ha
rmful foreign materials present in the periradicular area. Inflammator
y periradicular lesions (granuloma and cysts) are the responses of the
periradicular tissues to irritants from the root canal and not from t
he periradicular area unless medicaments and/or filling materials have
been forced through the apical foramina or perforations into the peri
odontium. Histologically, the inflammatory periradicular lesion is sim
ilar to healing granulation tissue, which is composed of cells which h
ave natural and specific immunological defence capability and cooperat
e by means of cytokines to amplify the protective mechanisms of the ho
st, Accordingly, it is not necessary to completely curette out all the
inflamed periradicular tissues during surgery, since this granulation
-like tissue will be incorporated into the new granulation tissue as p
art of the healing process. To control the source of irritants in the
root canal is far more important than to remove all periradicular tiss
ues affected by the irritants, The successful removal of all irritants
from the root canal system results in resolution of pulpally induced
periradicular lesions, In the case where the periradicular lesion is c
aused by endodontic instruments or cytotoxic filling materials placed
in the periradicular tissues, removal of these foreign objects is requ
ired for resolution of the lesion.