Erection is mainly, but not exclusively regulated by the parasympathet
ic nervous system. Emission and ejaculation are controlled by the symp
athetic nervous system. Somatic reflexes complete the neural pathways.
Until now validated specific neurophysiologic examinations of the aut
onomic innervation of the genital organs do not exist. Most of the neu
rophysiologic examinations test structures of the somatic sacral nervo
us system. In patients complaining of impotence the first diagnostic s
tep should be a thorough clinical examination and history taking. If t
here are signs or symptoms of a neurological disease the common neurop
hysiologic tests should be performed, if not it is not necessary to do
neurophysiologic examinations. However, tests of the thin or not myel
inated nerve fibers should be more sensitive in evaluating the cause o
f neurogenic impotence. The sensitivity and specifity of these tests r
emains to be further validated. At the moment the first therapeutic ap
proach is the local injection of vasoactive substances.