INVESTIGATIONS ON PREPARATION AND REACTIV ITY OF C-ANELLATED DERIVATIVES OF 1,3,4-BENZOTRIAZEPINES AND RELATED PRECURSORS N,N-COUPLED HETEROBICYCLES FROM CYCLIC HYDRAZINE DERIVATIVES .12.
O. Morgenstern et al., INVESTIGATIONS ON PREPARATION AND REACTIV ITY OF C-ANELLATED DERIVATIVES OF 1,3,4-BENZOTRIAZEPINES AND RELATED PRECURSORS N,N-COUPLED HETEROBICYCLES FROM CYCLIC HYDRAZINE DERIVATIVES .12., Die Pharmazie, 51(7), 1996, pp. 458-467
c-Anellated 1,3,4-benzotriazepines are hitherto unknown. In order to s
ynthesize derivatives of pyrazolo[1,2-c]- and phthalazino[2,3-c][1,3,4
]benzotriazepines the intramolecular cyclization of N-(N-arylthiocarba
moyl)-pyrazolidines and -1,2,3,4-tetrahydrophthalazines, respectively,
is investigated. The latter are prepared by reaction of pyrazolidine
and 1,2,3,4-tetrahydrophthalazine, respectively, with 2-functionalized
phenylisothiocyanates. Often the formation of derivatives of 3,1-benz
othiazines prevented by employment of suitable precursors is observed.