ENANTIOMERIC SEPARATION BY CAPILLARY ELECTROPHORESIS USING CHIRAL ANDACHIRAL ION-PAIRING REAGENTS

Investigations into the chiral separation by capillary electrophoresis (CE) using anionic and cationic ion pairing reagents were carried out . Camphersulfonic acid (CSA), sodium cyclamate, different alkane sulfo nic acids and quinine showed their ability to improve considerably the chiral discrimination of three basic drugs and two carboxylic acids i n the presence of cyclodextrins (CD), The depenence of the separation on the type of ion pairing reagent, pH-value and concentrations on ion pairing reagent and CD is described.