Chromatium species produced the novel biological thiol glutathione ami
de, gamma-L-glutamyl-L-cysteinylglycine amide (GASH), when grown photo
heterotrophically. GASH was largely converted to the corresponding per
thiol during photoautotrophic growth on sulfide, suggesting that GASH
may have a function in anaerobic sulfide metabolism. This unprecedente
d form of glutathione metabolism was probably present in anaerobic anc
estors of modern cyanobacteria acid purple bacteria.