DOUBLE-BLIND PARALLEL STUDY OF A COMBINATION OF CHLORTHALIDONE 50 MG AND TRIAMTERENE 50 MG IN PATIENTS WITH MILD AND MODERATE HYPERTENSION

In a double-blind, partial cross-over study of 141 patients with mild to moderate hypertension, chlorthalidone 50 mg was compared with chlor thalidone 50 mg/triamterene 50 mg combination treatment. The study ass essed clinical efficacy in the reduction of blood pressure, and safety with regard to serum potassium concentration and adverse reactions. B oth treatment regimens were found to offer equivalent therapeutic succ ess, but the decrease in serum potassium concentration was significant ly less with the combination treatment than with chlorthalidone alone.