TRUNCATED GLUCAGON-LIKE PEPTIDE-1 AND OXYNTOMODULIN STIMULATE SOMATOSTATIN RELEASE FROM RABBIT FUNDIC D-CELLS IN PRIMARY CULTURE

The ability of the proglucagon-derived peptides oxyntomodulin and trun cated glucagon-like peptide-1 (7-36) amide to stimulate somatostatin r elease from cultured rabbit fundic D-cells was assessed. Significant s timulation of somatostatin release was seen with both peptides at 10 n M. Potentiation of the stimulatory action of cholecystokinin was seen with both peptides at both 100 pM and 10 nM. The paracrine release of somatostatin from fundic D-cells may explain the acid inhibitory actio ns of the enteroglucagons. The different small bowel-derived peptides may interact at the level of the D-cell to regulate gastric acid secre tion.