Two sisters with documented Adamantiadis-Behcet's disease of different
severity, associated with HLA-B51, are described. Although the overal
l incidence of this complex disease is not different between sexes, on
ly 4 female siblings, versus 14 male, that fullfill the 1990's Interna
tional Study Group for Behcet's Disease criteria have been reported in
the literature.