EFFECT OF TITANOCENE DICHLORIDE COORDINATION ON WATSON-CRICK BASE-PAIRING

Authors
ZHANG ZG YANG P GUO ML WANG HF
Citation
Zg. Zhang et al., EFFECT OF TITANOCENE DICHLORIDE COORDINATION ON WATSON-CRICK BASE-PAIRING, Journal of inorganic biochemistry, 63(3), 1996, pp. 183-190
Citations number
22
Categorie Soggetti
Biology,"Chemistry Inorganic & Nuclear
Journal title
Journal of inorganic biochemistry → ACNP
ISSN journal
01620134
Volume
63
Issue
3
Year of publication
1996
Pages
183 - 190
Database
ISI
SICI code
0162-0134(1996)63:3<183:EOTDCO>2.0.ZU;2-O
Abstract
By high-resolution H-1 NMR and P-31 NMR, interactions between titanoce ne dichloride and 5'-AMP, 5'-TMP, 5'-AMP/5'-TMP have been investigated . The results suggest that titanocene dichloride disrupts Watson-Crick base pairing. On the basis of the NMR data, a new mechanism of antitu mor activity of titanocene dichloride is proposed.