GLIOBLASTOMA-MULTIFORME ARISING IN THE IRRADIATED SPINAL-CORD OF A RHESUS-MONKEY (MACACA-MULATTA)

An adult female rhesus monkey that had received 44.0 Gy of cobalt 60 r adiation to 8 cm of the cervical and upper thoracic spinal cord approx imately 2.8 years postirradiation developed a sudden onset of self-mut ilation and loss of function of the right arm followed progressively b y loss of function of the left ann and terminally bilateral paresis of the legs. Histopathologic examination of the cervical spinal cord rev ealed a glioblastoma multiforme that extended from the cervical medull ary junction to the sixth cervical vertebrae. Because of the infrequen t occurrence of spontaneous neoplasia in rhesus monkeys and the locati on in the radiation field, the glioblastoma is believed to be radiatio n induced.