Previous studies have shown that elevated basal homocysteine levels ar
e correlated among family members of patients with coronary vascular d
isease and juvenile venous thrombosis. This suggests the possibility o
f the presence of inherited basal mild hyperhomocysteinemia (mHH). We
studied homocysteine levels, fasting as well as after methionine load,
among 96 family members of 21 post-load hyperhomocysteinemic vascular
index patients, i.e. 6 parents, 27 offspring, 38 siblings, 19 uncles
and aunts and 6 cousins. In 15 out of 21 screened families post-load m
HH was established in at least one family member. Fasting and post-loa
d mHH was observed in 19 out of 89 (21%) screened family members (fast
ing homocysteine levels not measured in seven family members), and 31
out of 96 screened family members (32%), respectively. In 40% of all f
amily members, post-load mHH was not accompanied by fasting mHH. We co
nclude that both fasting and post-load mHH seems to be inherited in th
e majority of hyper-homocysteinemic vascular patients.