NOVEL-APPROACH TO THE SYNTHESIS OF THE AROMATASE INHIBITOR 4-HYDROXYANDROST-4-ENE-3,17-DIONE (4-OHA)

Authors
DASILVA EJT MELO MLSE NEVES ASC
Citation
Ejt. Dasilva et al., NOVEL-APPROACH TO THE SYNTHESIS OF THE AROMATASE INHIBITOR 4-HYDROXYANDROST-4-ENE-3,17-DIONE (4-OHA), Journal of the Chemical Society. Perkin transactions. I, (14), 1996, pp. 1649-1650
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
14
Year of publication
1996
Pages
1649 - 1650
Database
ISI
SICI code
0300-922X(1996):14<1649:NTTSOT>2.0.ZU;2-Z
Abstract
A straightforward synthesis of the title compound is achieved through a novel approach, comprising the oxidation of the easily available 5 a lpha-androst-3-en-17-one 1 in two sequential steps to yield the kineti c diosphenol 4, which gives the desired 4-OHA 5 by base-catalysed isom erization.