UK-2A, UK-2B, UK-2C AND UK-2D, NOVEL ANTIFUNGAL ANTIBIOTICS FROM STREPTOMYCES SP-517-02 .1. FERMENTATION, ISOLATION, AND BIOLOGICAL PROPERTIES

Authors
UEKI M ABE K HANAFI M SHIBATA K TANAKA T TANIGUCHI M
Citation
M. Ueki et al., UK-2A, UK-2B, UK-2C AND UK-2D, NOVEL ANTIFUNGAL ANTIBIOTICS FROM STREPTOMYCES SP-517-02 .1. FERMENTATION, ISOLATION, AND BIOLOGICAL PROPERTIES, Journal of antibiotics, 49(7), 1996, pp. 639-643
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
49
Issue
7
Year of publication
1996
Pages
639 - 643
Database
ISI
SICI code
0021-8820(1996)49:7<639:UUUAUN>2.0.ZU;2-6
Abstract
Novel antifungal antibiotics, UK-2A, B and a mixture of C and D, were obtained from the mycelial cake of Streptomyces sp. 517-02. All of the UK-2 compounds were similar in structure to antimycin A. The antifung al activities of UK-2 compunds were as strong as that of antimycin A. However, the UK-2 compounds demonstrated weak cytotoxicity compared to antimycin A.