METABOTROPIC GLUTAMATE-RECEPTOR ACTIVATION SELECTIVELY LIMITS EXCITOTOXIC DAMAGE IN THE INTACT NEOSTRIATUM

Authors
COLWELL CS ALTEMUS KL LEVINE MS
Citation
Cs. Colwell et al., METABOTROPIC GLUTAMATE-RECEPTOR ACTIVATION SELECTIVELY LIMITS EXCITOTOXIC DAMAGE IN THE INTACT NEOSTRIATUM, Brain research, 726(1-2), 1996, pp. 223-226
Citations number
19
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
726
Issue
1-2
Year of publication
1996
Pages
223 - 226
Database
ISI
SICI code
0006-8993(1996)726:1-2<223:MGASLE>2.0.ZU;2-2
Abstract
The present study was designed to compare the protective consequences of activation of metabotropic glutamate receptors (mGluRs) on N-methyl -D-aspartate (NMDA)- and kainic acid (KA)-induced excitotoxicity in vi vo. Pretreatment with the mGluR agonist 1SR,3RS-1-aminocyclo-pentane-1 ,3-dicarboxylic acid (tACPD) limited the anatomical and behavioral con sequences of the intrastriatal administration of the NMDA agonist quin olinic acid (QA). In contrast, pretreatment with tACPD did not alter t he effects of intrastriatal injection of KA.