PENTOSAN POLYSULFATE-INDUCED THROMBOCYTOPENIA - A CASE DIAGNOSED WITHAN ELISA TEST USED FOR HEPARIN-INDUCED THROMBOCYTOPENIA

We report a patient who developed severe thrombocytopenia and ischemic stroke following pentosan polysulfate treatment. An ELISA test employ ed in type-II heparin-induced thrombocytopenia was highly positive. To our knowledge, this is the first case in which this test has been per formed in a pentosan polysulfate-induced thrombocytopenia (PIT). Our d ata suggest that the antibody against pentosan polysulfate-platelet co mplex also cross-reacts with heparin-platelet factor 4 complex. Due to its greater sensitivity and wider availability, this ELISA test shoul d be used in cases where PIT is suspected.