INTRAVITREAL INJECTION OF AMIKACIN AND VA NCOMYCIN IS CONSIDERED A COMBINATION OF CHOICE BECAUSE OF ITS EFFICACY AND LACK OF TOXICITY AT USUAL DOSES

Case report Referred because of a right corneal perforation with cellu lar reaction in anterior chamber, a patient was sutured and treated wi th a single intravitreal injection of 0.2 ml (1 mg) Amikacin and 0.2 m l (1 mg) Vancomycin. Whereas the retina was normal before the injectio n, a diffuse retinal edema with intra- and preretinal hemorrhages was noted 12 hours postoperatively. Visual acuity was markedly reduced. ER G and visual field was also abnormal. Conclusion This case demonstrate s that a single intravitreal injection of Amikacin and Vancomycin at u sual concentration may induce retinal toxicity with permanent damage.