A CONVENIENT METHOD FOR THE PREPARATION OF 5-AZAINDOLES, 6-AZAINDOLESAND 7-AZAINDOLES AND THEIR DERIVATIVES

Authors
HANDS D BISHOP B CAMERON M EDWARDS JS COTTRELL IF WRIGHT SHB
Citation
D. Hands et al., A CONVENIENT METHOD FOR THE PREPARATION OF 5-AZAINDOLES, 6-AZAINDOLESAND 7-AZAINDOLES AND THEIR DERIVATIVES, Synthesis, (7), 1996, pp. 877
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
7
Year of publication
1996
Database
ISI
SICI code
0039-7881(1996):7<877:ACMFTP>2.0.ZU;2-#
Abstract
The directed ortho lithiation of 2-tert-butoxycarbonylamino-3-methylpy ridine (6 a) has provided a convenient method for the preparation of 1 H-pyrrolo[2,3-b]pyridine (4 a, 7-azaindole). This procedure has been u sed to prepare a range of 3-substituted 2-tert-butoxycarbonylaminopyri dines 6, 2- and 3-substituted and 2,3-disubstituted 1H-pyrrolo[2,3-b]p yridines 4 and shown to be of value in the preparation of 1H-pyrrolo[3 ,2-c]pyridine (15, 5-azaindole) and 1H-pyrrolo[2,3-c]pyridine (18, 6-a zaindole) and derivatives.