GENETIC DETERMINATION OF BONE-DENSITY

Citation
A. Baltzer et al., GENETIC DETERMINATION OF BONE-DENSITY, Zeitschrift fur Orthopadie und Ihre Grenzgebiete, 134(3), 1996, pp. 198-200
Citations number
27
Categorie Soggetti
Orthopedics
ISSN journal
00443220
Volume
134
Issue
3
Year of publication
1996
Pages
198 - 200
Database
ISI
SICI code
0044-3220(1996)134:3<198:GDOB>2.0.ZU;2-F
Abstract
Osteoporosis is a very common disease that concerns every forth postme nopausal white woman. The loss of bone density leads to fractures, mai nly to fractures of the neck of the femur. A herediterian geneses of t he ideopathic osteoporosis seems to be sure. The vitamin D receptor (V DR) has an important role for the mineralisation of the bones. His all elic variants can be used for a prediction of bone density. These alle les are correlated with endonuclease restriction areas for Bsm-1, Apa- 1 and Taq-1. Amoung these Bsm-1 has the highest incidence for predicti on. In this study the allelic variants of the VDR gene correlated with the bone density of the lumbar spine (p < 0.009).