Osteoporosis is a very common disease that concerns every forth postme
nopausal white woman. The loss of bone density leads to fractures, mai
nly to fractures of the neck of the femur. A herediterian geneses of t
he ideopathic osteoporosis seems to be sure. The vitamin D receptor (V
DR) has an important role for the mineralisation of the bones. His all
elic variants can be used for a prediction of bone density. These alle
les are correlated with endonuclease restriction areas for Bsm-1, Apa-
1 and Taq-1. Amoung these Bsm-1 has the highest incidence for predicti
on. In this study the allelic variants of the VDR gene correlated with
the bone density of the lumbar spine (p < 0.009).