Women (n=1443) expecting their first child were stud led to examine wh
ether prepregnancy headache predicts problems in the well-being of pre
gnant women and newborns. Subject collection was based on stratified r
andomized cluster sampling. Impairment of health during the first trim
ester was more often reported by women with frequent prepregnancy head
ache than by nonsufferers. They also made more visits to a doctor and
had more pregnancy symptoms during the third trimester. Use of any med
ication during the first trimester was also more common in the headach
e group. Mental health status was worse, fatigue and depression increa
sed during pregnancy more often, and stress and anxiety about delivery
were more common in this group. The relationship with spouses worsene
d during pregnancy in the headache group and seemed to be predicted by
impairment of somatic health during the first trimester and increasin
g depression during pregnancy. No statistical differences between grou
ps were found in variables measuring the well-being of the newborns. F
requent prepregnancy headache proved to be a strong predictor of ill-b
eing in pregnant women. This result should find practical applications
in the preventive work of maternity health care clinics.