Parenteral nutrition has been used in the nutritional management of lo
w-birthweight infants for the past 25 years. Nonetheless, many aspects
of the technique still are not completely understood. Further, other
aspects that are reasonably well understood frequently are not applied
in clinical practice. As a result, infants requiring this therapy fre
quently do not benefit maximally from it. Some of the important issues
concerning this technique are discussed, and some of the important qu
estions that need to be addressed are identified. Answers to many of t
hese important questions are necessary to further enhance the benefits
and diminish the undesired consequences of this therapy for infants w
ho require it.