SUBACUTE PANCEREBELLAR SYNDROME-ASSOCIATED WITH SYSTEMIC LUPUS-ERYTHEMATOSUS

A pancerebellar syndrome of subacute progression associated with cereb ellar atrophy is highly suggestive of a paraneoplastic cerebellar dege neration (PCD). We describe a 27-year-old woman with systemic lupus er ythematosus (SLE) that presented with a subacute pancerebellar syndrom e. Serum and CSF anti-Yo, anti-Hu and anti-Ri antibodies were not foun d neither in blood, nor in CSF. Brain MRI showed a cerebellar atrophy. The cerebellar ataxia improved markedly following corticosteroids adm inistration. This case probably demonstrates that an antineuronal anti body-negative subacute cerebellar disease may not only be a manifestat ion of paraneoplastic disease, but that it can also be associated with SLE.