OBSESSIVE-COMPULSIVE-DISORDER AND DEPRESSION - FIRST RESULTS OF A PROSPECTIVE-STUDY ON 74 PATIENTS

1. Seventy-four patients who met DSM-III-R criteria for Obsessive Comp ulsive Disorder received a serotonin reuptake inhibitor and cognitive behavior therapy for 6 months (baseline to follow-up I). 2. In order t o maximize therapeutic effects, different kinds of treatment were appl ied between follow-up I and follow-up II (12 months). 3. Patients were followed-up twice with respect to long-term outcome of obsessive comp ulsive disorder and depression. Forty % of the sample showed marked im provement at follow-up. No specific variant of treatment could be iden tified to be significantly more effective. 4. Cross-sectional investig ations showed significant correlations between extent of depressive an d obsessive compulsive symptomatology (admission, follow-up I and II).