CLINICAL AND PATHOLOGICAL CHARACTERISTICS OF PRIMARY PROGRESSIVE APHASIA AND FRONTAL DEMENTIA

The recently described conditions of primary progressive aphasia and f rontal lobe dementia overlap clinically and pathologically to a consid erable extent with each other and with clinical and pathological descr iptions of Pick's disease. Our clinical and neuropathological experien ce is summarized, leading us to the conclusion that the degree of over lap justifies the concept of ''Pick complex'' to include, in addition to the above, corticobasal ganglionic degeneration and some instances motor neuron disease with dementia.