THE BIOSYNTHESIS OF COLORADOCIN

Authors
MCALPINE JB MITSCHER LA JACKSON M RASMUSSEN RR VANDERVELDE D VELIZ E
Citation
Jb. Mcalpine et al., THE BIOSYNTHESIS OF COLORADOCIN, Tetrahedron, 52(31), 1996, pp. 10327-10334
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
31
Year of publication
1996
Pages
10327 - 10334
Database
ISI
SICI code
0040-4020(1996)52:31<10327:TBOC>2.0.ZU;2-R
Abstract
The biosynthesis of coloradocin involves assembly of a polyketide chai n similar to those of nargenicin and nodusmicin and an apparent non-po lyketide eleven carbon unit which incorporates acetate and succinate ( but not propionate) by some undetermined pathway. Precursor incorporat ion was studied using single and double labeled C-13 precursors and la bel scrambling was suppressed by the simultaneous addition of other un labeled substrates. Copyright (C) 1996 Elsevier Science Ltd