FACILITATION AND ATTENUATION OF SOCIAL RECOGNITION IN RATS BY DIFFERENT OXYTOCIN-RELATED PEPTIDES

Citation
P. Popik et al., FACILITATION AND ATTENUATION OF SOCIAL RECOGNITION IN RATS BY DIFFERENT OXYTOCIN-RELATED PEPTIDES, European journal of pharmacology, 308(2), 1996, pp. 113-116
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
00142999
Volume
308
Issue
2
Year of publication
1996
Pages
113 - 116
Database
ISI
SICI code
0014-2999(1996)308:2<113:FAAOSR>2.0.ZU;2-R
Abstract
The memory-modulating effects of subcutaneously administered oxytocin and related peptides were investigated in the social recognition parad igm in rats. The attenuation of social recognition by 0.6 and 6 mu g/k g of oxytocin was mimicked by the same doses of des-Gly(8)-oxytocin, [ pGlu(4),Cyt(6)]oxytocin-(4-9) and prolyl-leucyl-glycinamide (PLG) and by 0.6 mu g/kg of oxytocin-(1-6) and [pGlu(4),Cyt(6)]oxytocin-(4-8). T he peptide leucyl-glycinamide (LG) was not active in this respect. The facilitation of social recognition by 0.6 and 6 ng/kg of oxytocin was mimicked by the same doses of PLG and LG but not by the other peptide s and the amino acid glycine. It is concluded that the active moieties for attenuation and facilitation of social memory reside in different parts of the oxytocin molecule, e.g. the 5-7 and 8-9 region, respecti vely.