PHOSPHOLIPID-METABOLISM AND MEMBRANE DYNAMICS

Genetic and biochemical approaches are shedding new light on the disti nct physiological functions of specific phospholipid metabolic pathway s and the mechanisms by which phospholipids are mobilized between intr acellular compartments. In particular, phosphatidylinositol-transfer p roteins have recently been revealed to play fascinating and unanticipa ted roles in the coordination of phospholipid metabolism with vesicle- trafficking and signal-transducing reactions.