IS IMMUNOGENETIC SUSCEPTIBILITY TO NEUROPSYCHIATRIC SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE) DIFFERENT FROM NON-NEUROPSYCHIATRIC SLE

Citation
Lm. Silva et Ea. Donadi, IS IMMUNOGENETIC SUSCEPTIBILITY TO NEUROPSYCHIATRIC SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE) DIFFERENT FROM NON-NEUROPSYCHIATRIC SLE, Annals of the Rheumatic Diseases, 55(8), 1996, pp. 544-547
Citations number
16
Categorie Soggetti
Rheumatology
ISSN journal
00034967
Volume
55
Issue
8
Year of publication
1996
Pages
544 - 547
Database
ISI
SICI code
0003-4967(1996)55:8<544:IISTNS>2.0.ZU;2-J
Abstract
Objectives-To analyse frequency of HLA class II antigens (DR and DQ) a nd lymphocytotoxic autoantibodies in patients with systemic lupus eryt hematosus (SLE) and subsets with or without neuropsychiatric involveme nt. Methods-Ninety three patients with SLE (42 with neuropsychiatric f eatures) were typed for HLA class II antigens and investigated for the presence of lymphocytotoxic autoantibodies by a complement dependent microlymphocytotoxicity assay. A total of 191 controls of similar ethn ic background were also typed for HLA antigens. Results-HLA-DR3 antige n was increased in the total group of patients with SLE (p=0.003) and in the neuropsychiatric group (p=0.002). HLA-DR4 antigen frequency was increased in non-neuropsychiatric patients (p=0.001) and decreased in patients with neuropsychiatric SLE (p = 0.0005). Comparisons of HLA f requencies between subgroups of patients showed decreased HLA-DR4 (p<0 .0001) and increased HLA-DR9 and HLA-DQ2 antigens (p = 0.0008 and 0.00 5 respectively) in the neuropsychiatric group. The frequency of lympho cytotoxic autoantibodies was increased in neuropsychiatric patients wi th SLE having HLA-DR9 specificity (p = 0.04). Conclusion-HLA-DR4 may h ave a protective specificity for the development of neuropsychiatric f eatures of SLE and HLA-DR9, in addition to HLA-DR3, and the presence o f lymphocytotoxic autoantibodies may predispose to neuropsychiatric ab normalities.