SYNTHESIS OF THE 6-HYDROXYLATED AND 7-HYDROXYLATED COCAINE AND PSEUDOCOCAINES

Authors
KOZIKOWSKI AP SIMONI D MANFREDINI S ROBERTI M STOELWINDER J
Citation
Ap. Kozikowski et al., SYNTHESIS OF THE 6-HYDROXYLATED AND 7-HYDROXYLATED COCAINE AND PSEUDOCOCAINES, Tetrahedron letters, 37(30), 1996, pp. 5333-5336
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
30
Year of publication
1996
Pages
5333 - 5336
Database
ISI
SICI code
0040-4039(1996)37:30<5333:SOT6A7>2.0.ZU;2-6
Abstract
In efforts aimed at further exploration of our finding that functional ization of the two-carbon bridge of cocaine can lead to a weak antagon ist of cocaine, we report a route to the 6- and 7-hydroxylated analogu es by use of the Willstatter synthesis. The hydroxylated derivatives c an in principle be used to gain access to a diverse library of 6- and 7-functionalized cocaine analogues. Copyright (C) 1996 Elsevier Scienc e Ltd