SYNTHESIS OF AXINASTATIN-2 TO AXINASTATIN-5

The cytotoxic cyclic peptides axinastatin 2, 3, 4 and 5, isolated from the ocean marine sponges Axinella sp. and Axinella cf. carteri, were synthesized and characterized by FAB-MS and homo- and heteronuclear NM R spectroscopy. The synthetic compounds proved to be identical with th e natural products. The cyclization yield of axinastatin 5 could be in creased using structural information of a conformationaly comparable c ompound. In contrast to the published biological activity very low act ivities were found for all compounds. Copyright (C) 1996 Elsevier Scie nce Ltd