CORTICOSTEROID DERIVATIZATION - UNEXPECTED RESULTS OBTAINED USING N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL ON DEXAMETHASONE

Authors
NEGRIOLLI J MAUME D DENIAUD D ANDRE F
Citation
J. Negriolli et al., CORTICOSTEROID DERIVATIZATION - UNEXPECTED RESULTS OBTAINED USING N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL ON DEXAMETHASONE, Tetrahedron letters, 37(30), 1996, pp. 5365-5366
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
30
Year of publication
1996
Pages
5365 - 5366
Database
ISI
SICI code
0040-4039(1996)37:30<5365:CD-URO>2.0.ZU;2-8
Abstract
N,N-dimethylformamide dimethyl acetal, a methylating reagent, has been used on artificial corticosteroid dexamethasone to improve its GC-MS responsiveness. The major reaction product gave unexpected low resolut ion mass spectra. Its structure has been unambiguously determined. Thi s compound, a corticosteroid ester usually obtained after numerous rea ction steps', could be of great interest in the fields of analytical c hemistry and drug residues survey. Copyright (C) 1996 Elsevier Science Ltd