ZAMPANOLIDE, A NEW CYTOTOXIC MACROLIDE FROM A MARINE SPONGE

Authors
TANAKA J HIGA T
Citation
J. Tanaka et T. Higa, ZAMPANOLIDE, A NEW CYTOTOXIC MACROLIDE FROM A MARINE SPONGE, Tetrahedron letters, 37(31), 1996, pp. 5535-5538
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
31
Year of publication
1996
Pages
5535 - 5538
Database
ISI
SICI code
0040-4039(1996)37:31<5535:ZANCMF>2.0.ZU;2-N
Abstract
A novel 20-membered macrolide, zampanolide (3), has been isolated toge ther with latrunculin A (1) from a different collection of the sponge which previously yielded I and laulimalide (2). The gross structure of 3 was determined by 2D NMR and partial stereochemistry by NOE analysi s. It is a highly unsaturated 20-membered macrolide containing an unco mmon carbinol amine functionality. Zampanolide showed potent cytotoxic ity against several tumor cell lines. Copyright (C) 1996 Elsevier Scie nce Ltd