SEQUENCE DEPENDENCE OF THERMODYNAMIC STABILITY OF HETEROCHIRAL DNA

Authors
URATA H AKAGI M
Citation
H. Urata et M. Akagi, SEQUENCE DEPENDENCE OF THERMODYNAMIC STABILITY OF HETEROCHIRAL DNA, Tetrahedron letters, 37(31), 1996, pp. 5551-5554
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
31
Year of publication
1996
Pages
5551 - 5554
Database
ISI
SICI code
0040-4039(1996)37:31<5551:SDOTSO>2.0.ZU;2-8
Abstract
Several heterochiral dodecadeoxynucleotides (2-6) containing an unnatu ral L-enantiomer of D-deoxyribose were synthesized and their thermodyn amic stability for duplex formation was investigated. The results sugg ested that substitution of L-deoxyribose for natural D-deoxyribose som ewhat deceases the duplex stability, depending on the site that incorp orates the L-deoxynucleoside. Copyright (C) 1996 Elsevier Science Ltd