SYNTHESIS OF REACTIVE GAMMA-LACTAMS RELATED TO PENICILLINS AND CEPHALOSPORINS

Authors
DAVIES GM HITCHCOCK PB LOAKES D YOUNG DW
Citation
Gm. Davies et al., SYNTHESIS OF REACTIVE GAMMA-LACTAMS RELATED TO PENICILLINS AND CEPHALOSPORINS, Tetrahedron letters, 37(31), 1996, pp. 5601-5604
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
31
Year of publication
1996
Pages
5601 - 5604
Database
ISI
SICI code
0040-4039(1996)37:31<5601:SORGRT>2.0.ZU;2-B
Abstract
Gamma lactam analogues based on the penicillin and cephalosporin frame work have been synthesised which, in keeping with their design as pote ntial inhibitors of bacterial cell wall biosynthesis, show high reacti vity towards modest nucleophiles. An X-ray crystal structure of one of these compounds allows structural comparisons to be made with classic al beta-lactam antibiotics. Copyright (C) 1996 Elsevier Science Ltd