A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO ASSESS THE EFFECT OF FAMCICLOVIR ON VIRUS-REPLICATION IN PATIENTS WITH CHRONIC HEPATITIS-B VIRUS-INFECTION

Authors
MAIN J BROWN JL HOWELLS C GALASSINI R CROSSEY M KARAYIANNIS P GEORGIOU P ATKINSON G THOMAS HC
Citation
J. Main et al., A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO ASSESS THE EFFECT OF FAMCICLOVIR ON VIRUS-REPLICATION IN PATIENTS WITH CHRONIC HEPATITIS-B VIRUS-INFECTION, Journal of viral hepatitis, 3(4), 1996, pp. 211-215
Citations number
21
Categorie Soggetti
Gastroenterology & Hepatology","Infectious Diseases
Journal title
Journal of viral hepatitis → ACNP
ISSN journal
13520504
Volume
3
Issue
4
Year of publication
1996
Pages
211 - 215
Database
ISI
SICI code
1352-0504(1996)3:4<211:ADPSTA>2.0.ZU;2-1
Abstract
This is the first double-blind controlled study of famciclovir, an ora l antiviral agent, as potential therapy for chronic hepatitis B virus (HBV) carriers. A fall of more than 90% in HBV DNA levels was noted in six of 11 evaluable patients treated with a 10 day course of oral fam ciclovir. Further studies with more prolonged therapy are ongoing.