THE LEVEL OF PANCREATIC PLA(2) RECEPTOR IS CLOSELY ASSOCIATED WITH THE PROLIFERATIVE STATE OF RAT UTERINE STROMAL CELLS

Rat uterine stromal cells (U-III) express pancreatic type PLA(2) (PLA( 2)-I) receptor and internalize the enzyme bound to receptors, Here, we investigate the proliferating effect and alterations in binding of PL A(2)-I. There is a dramatic decline in PLA(2)-I binding in U-III cells as they progress from a nonconfluent proliferating state (40,000 site s/cell) to a confluent state (1300 sites/cell), Intracellular concentr ation of PLA(2)-I changed with the alteration in binding, suggesting t hat regulation in the PLA(2) binding capacity may have important impli cations in growth control mechanisms.