Background: The use of silicone oil in the treatment of hypertrophic s
cars has recently been much discussed, Silicone gel and silicone cream
containing 20% silicone oil have been demonstrated to effectively tre
at hypertrophic scars, However, the results in treating keloid are var
iable. Objective: The purpose of this study was to evaluate the clinic
al efficacy of silicone cream with occlusive dressing in the treatment
of keloid. Methods: An open study was performed in 15 Chinese patient
s with single or multiple keloids, Nineteen keloids were randomly sele
cted and treated with silicone cream occlusive dressing (SCOD). The ef
fectiveness was assessed using a scoring system involving elevation, r
edness, hardness, itching and tenderness or pain of the lesions, Resul
ts: Fifteen out of 19 keloids (79%) showed significant improvement aft
er using SCOD fur 6 months. None of the keloids progressed, Conclusion
s: We conclude that SCOD is easy to apply, noninvasive, painless, almo
st free of side effects, It is especially useful in children and those
who cannot tolerate the pain or inconvenience of other treatment proc
edures. The action mechanism of SCOD is still unclear, though hydratio
n and occlusion rather than silicone itself may play an important role
.