We report two syphilitic cases of indeterminable duration. The dramati
c cutaneous lesions of the female patient, compatible with secondary-t
ertiary syphilis associated with a positive VDRL reaction in CSF toget
her with the criteria of neurosyphilis in her male companion (despite
normal TPHA and IgG indices), led us to treat both of them in an optim
al way. The clinical and serological evolution was favourable.