POSITRON EMISSION TOMOGRAPHY FOR QUANTITATIVE-DETERMINATION OF GLUCOSE-METABOLISM IN NORMAL AND ISCHEMIC BRAINS IN RATS - AN INSOLUBLE PROBLEM BY THE HARDERIAN GLANDS

Authors
KUGE Y MINEMATSU K HASEGAWA Y YAMAGUCHI T MORI H MATSUURA H HASHIMOTO N MIYAKE Y
Citation
Y. Kuge et al., POSITRON EMISSION TOMOGRAPHY FOR QUANTITATIVE-DETERMINATION OF GLUCOSE-METABOLISM IN NORMAL AND ISCHEMIC BRAINS IN RATS - AN INSOLUBLE PROBLEM BY THE HARDERIAN GLANDS, Journal of cerebral blood flow and metabolism, 17(1), 1997, pp. 116-120
Citations number
20
Categorie Soggetti
Neurosciences,"Endocrynology & Metabolism",Hematology
Journal title
Journal of cerebral blood flow and metabolism → ACNP
ISSN journal
0271678X
Volume
17
Issue
1
Year of publication
1997
Pages
116 - 120
Database
ISI
SICI code
0271-678X(1997)17:1<116:PETFQO>2.0.ZU;2-J
Abstract
To examine the reliability of quantitative positron emission tomograph y studies in the rat (Rat-PET), we assessed the influence of radioacti vity accumulated in the Harderian glands on PET CMR(glc) determination . We measured CMR(glc) by PET and ex vivo dissection methods by using 2-[F-18]fluoro-2-deoxy-D-glucose in rats with and without focal brain ischemia. The CMR(glc) values obtained by PET, after correcting with r ecovery coefficients, were higher than those measured by the ex vivo m ethod at rostral slices, and reduction of the CMR(glc) in the ischemic brain was not demonstrated by PET in the frontal cortex, The radioact ivity accumulated in the Harderian glands prevents the quantitative de termination of CMR(glc) using Rat-PET.